Recently, international tourist has been increasing and mobility of human activity is increasing, so people have had more chance to contact with various cultures different from their own. In Japan, in anticipation of the 2020 Tokyo Olympic game, digital signage is expected to be an effective information presentation tool to improve cross-cultural understanding. In this study, four-frame comic was proposed to be an effective information presentation method, and an evaluation experiment was conducted to investigate how to make contents interesting or memorable by comparing four information presentation methods, four-frame comic, video, photograph and illustration. As a result of questionnaire conducted in the experiment, four-frame comic’s humorous story and readability could be effective to attract viewers’ interest and the amount of information included in four-frame comic and its humor expression could be effective to make viewers memorize information explained in presented contents. However, the effectiveness of four-frame comic was not significant. It was thought that the effect of information presentation methods is differ from topic type, and more detail experiment is expected to investigate the effective used of four-frame comic in future study.